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The largest GLP-1 study ever conducted was 2.4 million people through the U.S. Veteran's Affairs. GLP-1's like semaglutide and tirzepatide were found to reduce risk in 42 health conditions — making GLP-1's "one of the most exciting therapeutic tools in modern medicine."

Here's breakdown of the 42 health conditions found to be positively impacted 

🧠 Brain & Mental Health

• Alzheimer's disease

• Dementia

• Parkinson’s disease

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Understanding What’s Normal — and What It Really Means

Starting a GLP-1 medication like semaglutide or tirzepatide can be a turning point in your health journey — but it may come with a few physical changes that take you by surprise.

Let’s be clear: not everyone has side effects, and when they do happen, they’re usually short-lived, manageable, and often meaningful. Many of these changes are your body healing, not malfunctioning.

If you know what to expect and what it means, it becomes a lot easier to stay the course — and feel empowered.

The Most Common GLP-1 Side Effects (And Why They Happen)

Microdosing GLP‑1 medications (like semaglutide or tirzepatide) is gaining traction for metabolic health, disease prevention, and treating 42 other conditions, as well as weight management — in people with lower than 27 BMI.

I have partnered with a team of providers led by Dr. Brent Agin MD, a published expert in the peptide world with expertise spanning 25 years.

• Body mass management

• Enhance nutrient absorption / increase energy

• Neuroprotective benefits

The cost of GLP-1 treatments have kept far too many people from getting the help they need. Insurance coverage is hit-or-miss, name-brand prescriptions can exceed $1,000 per month, and many providers won't even offer them unless you meet strict criteria.

So what are people doing instead?

Without insurance, they’re turning to compounded semaglutide or tirzepatide — and for good reason.

Why Consider Compounded GLP-1?

Compounded GLP-1 medications are prescribed by licensed medical providers and custom-made for you in sterile 503A compounding pharmacies regulated by state boards and operating under FDA guidelines.

Headline warnings about “salt forms” like semaglutide sodium or tirzepatide acetate caused unnecessary concern. The issue wasn’t with licensed compounding pharmacies — it was with unregulated research peptides sold online, often labeled “not for human consumption.”

Unfortunately, some early media stories — and even tools like ChatGPT — failed to explain the difference.

That led many to believe legitimate compounded medications were unsafe, when in fact, compounded GLP-1s from licensed 503A pharmacies are FDA-regulated, patient-specific, third-party tested for sterility and purity -- and trusted by medical professionals.

Scott Brunner, CEO of the Alliance for Pharmacy Compounding, addressed this directly: