GLP-1 Talk

The largest GLP-1 study ever conducted was 2.4 million people through the U.S. Veteran's Affairs. GLP-1's like semaglutide and tirzepatide were found to reduce risk in 42 health conditions — making GLP-1's "one of the most exciting therapeutic tools in modern medicine."

Here's breakdown of the 42 health conditions found to be positively impacted 

🧠 Brain & Mental Health

• Alzheimer's disease

• Dementia

• Parkinson’s disease

• Anxiety disorders

• Depression

• Psychotic disorders

• Substance use disorders (including alcohol use)
  

💓 Cardiovascular & Circulatory

• Heart failure

• Coronary artery disease

• Atrial fibrillation

• Stroke

• Hypertension (high blood pressure)

• Venous thromboembolism (blood clots)
  

💨 Respiratory

• Asthma

• Chronic obstructive pulmonary disease (COPD)

• Pneumonia
  

🧬 Metabolic & Endocrine

• Type 2 diabetes

• Hyperlipidemia (high cholesterol)

• Obesity

• Polycystic ovary syndrome (PCOS)
  

🩺 Liver & Digestive

• Fatty liver disease (NAFLD)

• Cirrhosis

• Gallstones

• Pancreatitis
  

👁️ Vision & Eye Health

• Diabetic retinopathy

• Macular degeneration

• Glaucoma
  

🦴 Musculoskeletal & Joint

• Osteoarthritis

• Rheumatoid arthritis

• Gout

• Low back pain
  

🧪 Kidney & Urinary

• Chronic kidney disease (CKD)

• Urinary tract infections (UTIs)

🔬 Cancer & Immune-Related

• Certain cancers (e.g., colorectal, possibly breast)

• Psoriasis

• Systemic lupus erythematosus
  

🩹 Other / General Inflammation

• Chronic fatigue syndrome

• Chronic Lyme

• Long COVID

• Anemia

• Infections
  

⚠️ 19 Conditions With Increased Risk

The same study also flagged a modest increase in risk for 19 outcomes, mainly related to gastrointestinal side effects, such as:

• Gastroparesis (delayed stomach emptying)

• Nausea

• Vomiting

• Diarrhea

• Pancreatic enzyme changes

(Note: These risks were not severe or long-lasting in most users and are well-known GLP-1 side effects.)